At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere strand disrupting the double-helical DNA, and base pairing to …

3 days ago · A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming frayed or tangled. Each time a …

Aug 4, 2025 · The telomere’s role in aging becomes clear when you realize they’re not endlessly replenished. In most somatic (body) cells, telomeres shorten with every division, slowly ticking …

While telomere shortening has been linked to the aging process, it is not yet known whether shorter telomeres are just a sign of aging like gray hair or actually contribute to aging.

The interplay between telomere-associated proteins and telomerase, which sets the appropriate telomere length in different cellular stages and cell types, is an area that also requires rigorous …

Mar 30, 2025 · Telomere length varies between individual chromosomes, they do not have the same telomere length in all individuals. This can affect the measurement of telomeres.

The Telomere Clinic at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins provides multidisciplinary care to patients who are suspected to have or who carry the …

Nov 20, 2025 · telomere, segment of DNA occurring at the ends of chromosomes in eukaryotic cells (cells containing a clearly defined nucleus). Telomeres are made up of repeated …

Jul 31, 2025 · During cell division, the DNA replication machinery cannot fully copy the very end of a chromosome, leading to a slight shortening of the telomere with each round of division.

Nov 29, 2024 · This Review discusses telomere maintenance and damage, and recent efforts to generate ‘humanized’-telomere mouse models.