Human homeostatic iron regulator protein, also known as the HFE protein (H igh FE 2+), is a transmembrane protein that in humans is encoded by the HFE gene. The HFE gene is located …

The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells. Learn about this gene and related health conditions.

Linked to the major histocompatibility complex (MHC) on chromosome 6p, HFE encodes the MHC class I-like protein HFE that binds beta-2 microglobulin. HFE influences iron absorption by …

May 15, 2024 · Hereditary hemochromatosis is most commonly caused by certain changes in a specific gene, called the HFE gene. If you inherit two of these genetic changes (mutations), …

Nov 13, 2025 · HFE (Homeostatic Iron Regulator) is a Protein Coding gene. Diseases associated with HFE include Hemochromatosis, Type 1 and Microvascular Complications Of Diabetes 7.

Hereditary hemochromatosis is a genetic disorder characterized by excessive iron (Fe) accumulation that results in tissue damage. Manifestations can include systemic symptoms, …

Jul 31, 2025 · Explore the HFE genetic mutation, its impact on the body’s essential functions, and how this common inherited variant can influence health.

Jan 9, 2025 · Hemochromatosis (he-moe-kroe-muh-TOE-sis) is a condition that causes the body to absorb too much iron from food. Excess iron is stored in the organs, especially the liver, …

Apr 22, 2024 · This topic reviews the genetics and functions of the HFE gene and other genes associated with hereditary hemochromatosis (HH) syndromes, including some of the more …

Hemochromatosis gene (HFE) testing is a blood test used to check for hereditary hemochromatosis, an inherited disorder that causes the body to absorb too much iron.