Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 1.5-point favorites, according to the latest 49ers vs.

The San Francisco 49ers are used to playing shorthanded, but this week they will also face a foe that is coming in without ...

Looking for a best bet for Sunday’s NFL action? You’ve come to the right place, as the SI Betting team has been making ...

San Francisco's Christian McCaffrey and George Kittle pose challenges for Houston's defense, and 49ers' pass rush will be key ...

49ers 24, Texans 16: San Francisco may be without defensive pillars Nick Bosa and Fred Warner, but the Houston offense has ...

Witness rising stars and established anchors collide. These defensive playmakers will dictate the outcome when 49ers face ...

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.

Meanwhile, the Texans haven't been as fortunate to begin the 2025 campaign. Houston has started 2-4 and is fresh off a 27-19 ...

Facing a team with a 2-4 record would typically be favorable the San Francisco 49ers. However, the Houston Texans aren't a ...

Preview the Week 8 matchup between the Houston Texans and San Francisco 49ers with predictions, odds, over/under, spread, ...

The 49ers' top quarterback has missed five of seven games this season so far. Here's the latest on his status for Week 8.

San Francisco 49ers quarterback Brock Purdy has been ruled out for his team's Week 8 matchup against the Houston Texans amid ...