Anti-transferrin receptor (TfR) antibody-coupled acid-alpha-glucosidase (GAA) led to robust glycogen clearance and reduced neuroinflammation in the central nervous system of a mouse model of Pompe ...
As glucose levels increased, sepsis-related mortality also increased: 0.9% in the euglycemic group, 3.5% in the mild hyperglycemia group, and 19.3% in the overt hyperglycemia group. Hyperglycemia is a ...
The patient was diagnosed with primary diffuse large B-cell lymphoma (DLBCL) of the optic nerve based on histopathologic analysis of biopsy. Researchers from Poland reported the case of a patient with ...
Results support incorporating discussions of adverse events alongside efficacy in shared treatment decision-making. Progression-free survival (PFS) and the impact of adverse events (AEs) on quality of ...
Patients with AATD had a 1.6-fold higher risk of any type of middle ear surgery, even after adjusting for age, sex, COPD, and liver cirrhosis. Patients with alpha-1 antitrypsin deficiency (AATD) are ...
The highest risks were observed for bladder cancer, leukemia, nonmelanoma skin cancer, and kidney cancer. Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have a ...
Rare Disease Advisor, a trusted source of medical news and feature content for healthcare providers, offers clinicians insight into the latest research to inform clinical practice and improve patient ...
CLL-related immune dysfunction, along with therapy-associated immunosuppression, contributes to impaired tumor surveillance. Patients with chronic lymphocytic leukemia (CLL) are at increased risk for ...
Despite his kappa-restricted gammopathy and suspicion of AL amyloidosis, further investigation yielded the accurate diagnosis. Transthyretin amyloid cardiomyopathy (ATTR-CM) can present with a ...
Decreased nailfold capillary density, exertional dyspnea, and exertional palpitations were significant predictors of exercise pulmonary hypertension. Exercise pulmonary hypertension (PH) was ...
Independent predictors of poor survival in HCC included male sex, older age, unmarried status, and advanced-stage disease. The effect of fibrosis on survival in hepatocellular carcinoma (HCC) varies ...
The potential of vitamin D as an add-on therapy lies in its immunomodulatory effect on T cell-mediated and humoral immune responses, complement activation, cytokines, and inflammasomes. Vitamin D ...
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