EMBO Press

circ-EGFR is a predictor of response to Cetuximab and a potential target in colorectal cancer

Circ-EGFR was identified as a novel predictive biomarker for cetuximab efficacy in KRAS wild-type metastatic colorectal ...
EMBO Press

Closing the loop on EGFR therapy: decoding cetuximab response through circ-EGFR

Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...
The EMBO Journal

Paraspeckles are constructed as block copolymer micelles

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Paraspeckles are constructed by NEAT1_2 ...
EMBO Press

Mechanism of autophagy initiation by transmembrane selective autophagy receptors

Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby safeguarding cellular homeostasis. This process relies on selective ...
The EMBO Journal

MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In this study miR-33a/b were identified as ...
EMBO Press

A mammalian-like piRNA pathway in Axolotl reveals the origins of piRNA-directed DNA methylation

RNA-directed DNA methylation of active transposons in the germline is believed to be a mammalian innovation. This study ...
EMBO Press

Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons

TIA1 is a prominent RNA binding protein (RBP) involved in the formation of pathogenic aggregates in neurons. This manuscript ...
The EMBO Journal

Early coordination of cell migration and cardiac fate determination during mammalian gastrulation

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During gastrulation, mesodermal cells derived ...
The EMBO Journal

Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Osimertinib is the first-line therapy for EGFR ...
The EMBO Journal

Spatial transcriptomics elucidates localized immune responses in atherosclerotic coronary artery

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Atherosclerosis is characterized by the ...
The EMBO Journal

Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation

Bipolar spindle assembly and chromosome biorientation are prerequisites for chromosome segregation during cell division. The kinesin motor KIF11 (also widely known as Eg5) drives spindle ...
The EMBO Journal

The proteostatic landscape of healthy human oocytes

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Oocytes, female germ cells that develop into ...