Short or tall? Curly hair or straight? DNA holds those answers, but it can also reveal much more. In the September 8 issue of Nature Genetics, scientists led by Aliza and Thomas Wingo at the ...

The infamous paired helical filaments (PHFs) of tau that sprawl across the brain in Alzheimer’s disease are the end products of a multiyear process. What drives tau to form these specific filaments in ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

This interactive resource organizes decades of data on biomarkers for Alzheimer's disease. Biomarker measurements from the cerebrospinal fluid and blood are curated from the primary literature and ...

Species: Mouse Genes: SNCA Modification: SNCA: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6;DBA-Tg(Thy1-SNCA)61Ema Genetic Background: (C57BL/6 x DBA/2)F1 (strain of origin) ...

Gotcha! Scientists spot where, and possibly how, p-tau217 first appears in the brain. In a postmortem study of individuals spanning the Alzheimer’s disease spectrum, researchers led by Michiko Sekiya ...

Blood draws from across sub-Saharan Africa are underway. Samples are shipped from Nigeria to Miami. There, their genetics and biomarkers are being analyzed. According to the most recent Global Burden ...

It’s official: A new AI consortium to speed the pace of discoveries in AD research is off to the races. Its name? C-brAIn, emphasis evoking artificial intelligence intended. Alzforum first reported on ...

With amyloid immunotherapy in clinical use, scientists need to find better ways to identify the patients most at risk of developing ARIA (see part 16 of this series). One of the biggest danger signs, ...

The current Alzheimer’s disease therapeutic antibodies carry a sizable risk of ARIA, especially for APOE4 carriers. Researchers believe the future of amyloid immunotherapies lies in targeted brain ...

Friend or foe? The debate about disease-associated microglia persists eight years after their discovery. If only there was a way to interrogate DAMs in living people and see how they correlate with ...