The San Francisco 49ers have had a tough time with the Arizona Cardinals since head coach Kyle Shanahan took over in the 2017 season.

The San Francisco 49ers could completely flip their QB depth chart with Brock Purdy working through a toe injury.

The San Francisco 49ers and Arizona Cardinals will meet on Sunday for an NFC West battle in Week 3. Here's what fans should know before the game.

The San Francisco 49ers and Arizona Cardinals will meet on Sunday. Here's what fantasy owners should do with their 49ers in Week 3.

Head coach Kyle Shanahan on Friday told reporters new starting left guard Connor Colby suffered a groin injury that will make him questionable for the 49ers' home opener Sunday vs. the Arizona ...

The San Francisco 49ers may have one of the best linebacker duos in the NFL today, and one of their legends recognizes it.

The San Francisco 49ers may have to dig deep into their depth chart to find a starting left guard alongside Trent Williams in Week 3.

San Francisco 49ers fans took over Caesars Superdome on Sunday against the New Orleans Saints, and Saints defensive end ...

The San Francisco 49ers will begin Week 3 with even more injury questions than they had lingering into Week 2.

Brown, a third-round pick and the 49ers' first selection in the 2023 draft, was moved to the bench after starting 13 of the ...

The San Francisco 49ers will take on the Arizona Cardinals this weekend. Here's what the experts think will happen on Sunday at Levi's Stadium ...

The San Francisco 49ers defeated the New Orleans Saints on Sunday. Here's who had the best and worst days, according to Pro ...