Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. It is commonly caused by efflux of anticancer drugs by ABC transporters including ABCG2. ABCG2 is also a cancer stem cell ...

(A) Venn diagram of the intersection of differentially expressed circRNAs among the three datasets. (B, C) Heatmaps of six HCC-related differentially expressed circRNAs in the GSE235991 and GSE121714 ...

Abstract: MicroRNAs (miRNAs) are reported to play essential roles in cancer initiation and progression and microarray technologies are intensively applied to study the miRNA expression profile in ...

The development of obesity-associated comorbidities such as type 2 diabetes (T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; however, an unbiased genome-wide ...

BACKGROUND: We have shown that the late-pregnant (LP) rodent exhibits a higher susceptibility to myocardial ischemia-reperfusion injury (IRI) compared to non-pregnant (NP). The molecular mechanisms ...

Background Harlequin ichthyosis (HI) is a rare skin disorder with extremely high lethality due to a mutation of the ABCA12 gene. Because of its rarity and the often-late onset, prenatal screening for ...

Reproducible translation of transcriptomics data has been hampered by the ubiquitous presence of batch effects. Statistical methods for managing batch effects were initially developed in the setting ...

1 Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China 2 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China Objective: The ...