SportsLine's model simulated Arizona Cardinals vs. San Francisco 49ers 10,000 times and made its Week 5 NFL picks, ...

San Francisco will have to wear their red jerseys at home during record heat, despite Kyle Shanahan's request to wear white.

What to look for from the top 49ers and Cardinals players and how to watch the game as they face off on Sunday, week 5.

Head coach Kyle Shanahan told reporters Friday that the team put in a request to the NFL to switch from their usual red home ...

Amid what constitutes scalding conditions for Northern California, 49ers coach Kyle Shanahan told reporters Friday that the ...

On Sunday in San Francisco (Santa Clara), record heat for early October is expected. With a projected high of 95, the 49ers ...

Preview the Week 5 matchup between the San Francisco 49ers and Arizona Cardinals with predictions, odds, over/under, spread, ...

The league rejected the Niners and they will have to wear the darker uniforms despite the heat wave. Head coach Kyle Shanahan ...

An NFLPA request to halt media locker room access led to shots fired from 49ers fullback Kyle Juszczyk.

In a scorching twist for Sunday's game, the NFL has denied the San Francisco 49ers' request to wear white uniforms for their ...

San Francisco 49ers' stars George Kittle and Fred Warner are dealing with injuries, and here is the latest on their playing ...