Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

In this study, we provide a detailed molecular analysis of the KMN subunit Kre28 Zwint. We identified a conserved Zwint helix in Kre28 whose lack leads to fatal chromosome segregation defects when ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

Corneal diseases can cause severe visual impairment and even blindness, which have been linked to the interruption of corneal epithelial homeostasis. However, the underlying molecular mechanisms are ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

The endoplasmic reticulum (ER) of the eukaryotic cell is the major site of lipid and membrane protein synthesis, and it acts as a hub for intracellular communication. This organelle extends from the ...

mTOR plays a pivotal role in cancer growth control upon amino acid response. Recently, CDK inhibitor P27KIP1 has been reported as a noncanonical inhibitor of mTOR signaling in MEFs, via unclear ...

Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in ...

To address a wide range of genetic diseases, genome editing tools that can achieve targeted delivery of large genes without causing double-strand breaks (DSBs) or requiring DNA templates are necessary ...

Biological mechanisms related to cancer development can leave distinct molecular fingerprints in tumours. By leveraging multi-omics and epidemiological information, we can unveil relationships between ...