This interactive resource organizes decades of data on biomarkers for Alzheimer's disease. Biomarker measurements from the cerebrospinal fluid and blood are curated from the primary literature and ...

Antisense oligonucleotides have emerged as a promising approach for treating neurodegenerative disease. They can dial down toxic proteins or help restore functional ones, and have been approved for ...

The infamous paired helical filaments (PHFs) of tau that sprawl across the brain in Alzheimer’s disease are the end products of a multiyear process. What drives tau to form these specific filaments in ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

Species: Mouse Genes: SNCA Modification: SNCA: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6;DBA-Tg(Thy1-SNCA)61Ema Genetic Background: (C57BL/6 x DBA/2)F1 (strain of origin) ...

Gotcha! Scientists spot where, and possibly how, p-tau217 first appears in the brain. In a postmortem study of individuals spanning the Alzheimer’s disease spectrum, researchers led by Michiko Sekiya ...

With amyloid immunotherapy in clinical use, scientists need to find better ways to identify the patients most at risk of developing ARIA (see part 16 of this series). One of the biggest danger signs, ...

While amyloid immunotherapy is slowly becoming more accepted in clinical use, its biggest drawback remains the risk of ARIA. Scientists continue to study which patients are most at risk, how to ...

Friend or foe? The debate about disease-associated microglia persists eight years after their discovery. If only there was a way to interrogate DAMs in living people and see how they correlate with ...

This year’s AAIC spotlighted a sprawling network of tunnels. No, not the Toronto subway, but tunneling nanotubes—thin membranous tendrils that sprout from the cell membrane to form connections with ...

Blood draws from across sub-Saharan Africa are underway. Samples are shipped from Nigeria to Miami. There, their genetics and biomarkers are being analyzed. According to the most recent Global Burden ...

A selected list of scientific conferences relevant to researchers, clinicians and others interested in Alzheimer’s disease and related neurodegenerative disorders.