Lupus Science & Medicine

Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren’s syndrome

Objectives The central nervous system is a significant extraglandular target in primary Sjögren’s syndrome (pSS), often ...
Lupus Science & Medicine

Prevalence and determinants of vertebral fractures in a SLE cohort

Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by multiorgan involvement.
lupus.bmj

Glycosylation of anti-dsDNA IgG correlates with organ involvement in treatment-naïve patients with systemic lupus erythematosus

Objective This study aimed to leverage machine learning algorithms to explore the relationship between anti-double-stranded DNA (anti-dsDNA) immunoglobulin G (IgG) glycosylation and the degree of ...
lupus.bmj

24 Phase 1 study in healthy volunteers to assess PK, PD safety & tolerability of BOS161721, an extended half-life anti-IL21 monoclonal antibody

Background Interleukin-21 (IL-21) is a pleiotropic cytokine. Both IL-21 and the IL-21 receptor (IL-21R) have been shown to be upregulated in systemic lupus erythematosus (SLE). BOS161721, a humanized ...