The San Francisco 49ers have had a tough time with the Arizona Cardinals since head coach Kyle Shanahan took over in the 2017 ...

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 3 schedule and just locked in its top ...

The 49ers’ home opener has their defensive focused on Arizona’s Kyler Murray, who threw for four touchdown passes in one win ...

Brock Purdy has practiced back-to-back days and called his toe injury "a day-to-day thing," with the 49ers' Week 3 matchup against the Arizona Cardinals looming.

Check out the full 2025 NFL Week 3 schedule below. Thursday, Sept. 18: Sunday, Sept. 21: 8:15 p.m. ET – Detroit Lions vs.

The Cardinals earned their second win last week nearly blowing a 27-3 lead before ultimately holding on for a 27-22 victory. Arizona failed as a team to gain 300 yards in the game (292) and committed ...

When Kyler Murray is at his best, he can be a nightmare for the opposition with his ability to break off long runs, avoid sacks and extend plays doing damage to even ...

Some of the site's predictions differ from NFL Week 3 odds and other NFL Week 3 picks for NFL Week 3 games. How correct will the analytics be this week? Click on each game for more NFL Week 3 ...

Now that every NFL team has played multiple games this season, we've seen considerable movement in terms of playoff odds at ...

The San Joaquin Regional Rail Commission is offering its ACE special train service to Levi's Stadium starting Sunday, Sept.

What TV channel is Arizona Cardinals vs San Francisco 49ers game on? Time, how to watch on television, how to stream NFL Week 3 game Sunday, Sept. 21.

Troy Merritt lost his full PGA Tour card last year and didn't let that stop him from a full schedule. Merritt has taken ...