Date: Sunday, Sept. 21 | Time: 4:25 p.m. ET Location: Levi's Stadium -- Santa Clara, California TV: Fox | Stream: NFL + Follow: CBS Sports App Odds: 49ers -3; O/U 43.5 (via DraftKings) ...

San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under ...

The San Francisco 49ers have had a tough time with the Arizona Cardinals since head coach Kyle Shanahan took over in the 2017 season.

The 49ers’ home opener has their defensive focused on Arizona’s Kyler Murray, who threw for four touchdown passes in one win ...

The Arizona Cardinals ' next game comes Sunday afternoon against the San Francisco 49ers. It is a Sunday afternoon game, ...

Brock Purdy has practiced back-to-back days and called his toe injury "a day-to-day thing," with the 49ers' Week 3 matchup against the Arizona Cardinals looming.

Check out the full 2025 NFL Week 3 schedule below. Thursday, Sept. 18: Sunday, Sept. 21: 8:15 p.m. ET – Detroit Lions vs.

The Cardinals earned their second win last week nearly blowing a 27-3 lead before ultimately holding on for a 27-22 victory. Arizona failed as a team to gain 300 yards in the game (292) and committed ...

When Kyler Murray is at his best, he can be a nightmare for the opposition with his ability to break off long runs, avoid sacks and extend plays doing damage to even ...

Some of the site's predictions differ from NFL Week 3 odds and other NFL Week 3 picks for NFL Week 3 games. How correct will the analytics be this week? Click on each game for more NFL Week 3 ...

Now that every NFL team has played multiple games this season, we've seen considerable movement in terms of playoff odds at ...

The San Joaquin Regional Rail Commission is offering its ACE special train service to Levi's Stadium starting Sunday, Sept.