Covariate-adaptive randomization represents an advanced methodology in the design of clinical trials, ensuring a balanced distribution of prognostic factors among treatment groups. This approach ...

The equipoise randomization strategy allowed patients to indicate a preference to which of the level 2 options they would accept or refuse. Only 1% of the cohort would accept all 7 treatment options.

In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients ...

Randomization Techniques (60 minutes): In this workshop, the rationale behind randomized experiments will be explained. Descriptions of commonly utilized randomization algorithms will be presented, ...

Icotrokinra is a first-in-class oral peptide drug that selectively inhibits the IL-23 receptor, disrupting IL-23 signaling ...

Mortality Benefit of a Blood-Based Biomarker Panel for Lung Cancer on the Basis of the Prostate, Lung, Colorectal, and Ovarian Cohort Data of the randomized PORTEC-1 trial (n = 714) comparing pelvic ...

MANCHESTER, England — Two new randomized controlled trials (RCTs) assessing the role of rituximab in the treatment of various stages of systemic lupus erythematosus (SLE) have the green light to start ...

The cyclooxygenase inhibitor ibuprofen may be used to treat patent ductus arteriosus (PDA) in preterm infants. Whether selective early treatment of large PDAs with ibuprofen would improve short-term ...

Constitutional Epimutations: From Rare Events Toward Major Cancer Risk Factors? We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing ICIs combined with ...

A Swedish-led research team at Karolinska Institutet and Karolinska University Hospital has shown in a new randomized ...