More information: Jamie A. Abbott et al, Allosteric inhibition of NMDA receptors by low dose ketamine, Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02729-9 Provided by University at Buffalo ...

In a paper published on June 12 in the journal Cell Reports, UC Davis researchers show that a wide range of psychedelic drugs, including LSD and MDMA, impact the structure and function of neurons ...

This compound, originally known as CI-581, was eventually named ketamine based on the ketone and amine group that formed its chemical structure. Followings its discovery, ketamine was then used in ...

Scientists Tweaked LSD’s Molecular Structure and Created a Wild New ... it also proved a powerful antidepressant in early experiments involving mice at doses 100-fold lower than ketamine, ...

Behavioral studies also hint at the similarities between psychedelics and ketamine. In another recent paper published in ACS Chemical Neuroscience, Olson’s group showed that DMT treatment enabled rats ...

Since this observation was published in the early 2000s, ketamine clinics, where the drug is administered intravenously to treat depression, have been established in cities nationwide. But just how ...

Esketamine (or s-ketamine) is an enantiomer of ketamine (with similar molecular structure), and the journal Medicine reports esketamine is approximately twice as potent as ketamine.

A World Health Organization Essential Medicine, ketamine is widely used at varying doses for sedation, pain control, general anesthesia and as a therapy for treatment-resistant depression. While ...

Ketamine has been used since the 1960s as an anesthetic, but in 2000, the first trial of far lower doses of ketamine proved its rapid efficacy in treating major depression and suicidal ideation.

Since this observation was published in the early 2000s, ketamine clinics, where the drug is administered intravenously to treat depression, have been established in cities nationwide. But just how ...

Researchers made small tweaks to the molecular structure of LSD to see if ... it also proved a powerful antidepressant in early experiments involving mice at doses 100-fold lower than ketamine, ...

But, the channels of the receptor can be blocked by a molecule. Blocking by magnesium helps to naturally regulate ion flow. Ketamine, however, is an especially effective blocker. Blocking slows the ...