eLife

Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in ...
eLife

Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion

Department of Cell Science, Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University, Japan; Biomedical Research Institute, National Institute of Advanced Industrial Science ...
eLife

A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

Investigation of neuromodulatory control of ethologically conserved area-restricted food search behavior shows that NLP-12 stimulation of the head motor circuit promotes food searching through the ...
eLife

On the dimensionality of odor space

There is great interest in understanding human olfactory experience from a principled and quantitative standpoint. The comparison is often made to color vision, where a solid framework with a ...
eLife

Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

This study reports a comparative biochemical and structural analysis of two PLP decarboxylase enzymes from plants. The work is useful because of the potential application of these enzymes in ...
eLife

Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

The majority of mitochondrial proteins are targeted to mitochondria by N-terminal presequences and use the TIM23 complex for their translocation across the mitochondrial inner membrane. During import, ...
eLife

Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of pathways that remodel the mitochondrial ...
eLife

SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

This manuscript focuses on developing a structural model of how the multidomain ECM protein SVEP1 enables Angiopoietin (ANG) binding to the orphan receptor TIE1, resulting in downstream receptor ...
eLife

Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis

The synergy between aging and injury impairs alveolar progenitor functions leading to progressive lung fibrosis.
eLife

A brainstem circuit controls cough-like airway defensive behaviors in mice

This valuable study by Xu and colleagues investigates brainstem circuits mediating evoked respiratory reflexes that they define as cough-like in a freely behaving mouse model. They have applied ...
eLife

Role of direct and indirect social and spatial ties in the diffusion of HIV and HCV among people who inject drugs: a cross-sectional community-based network analysis in New ...

The median age was 26; 99% were male. Baseline HIV prevalence was 37.0% and 46.8% were actively infected with HCV (HCV RNA positive). The odds of prevalent HIV and active HCV infection decreased with ...
eLife

Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

The authors of this manuscript address the following question in the immunology field: what are the transcriptional regulators that allow macrophages to assume different functional phenotypes in ...