BMJ

A clinical tool for predicting survival in ALS

Background Amyotrophic lateral sclerosis (ALS) is a progressive and usually fatal neurodegenerative disease. Survival from diagnosis varies considerably. Several prognostic factors are known, ...
BMJ

Anti-CASPR2 clinical phenotypes correlate with HLA and immunological features

Objective Antibodies against contactin-associated protein-like 2 (CASPR2-Abs) have been described in acquired neuromyotonia, limbic encephalitis (LE) and Morvan syndrome (MoS). However, it is unknown ...
BMJ

CLOX: an executive clock drawing task

Associate Professor D R Royall, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284–7792, USA. Telephone 001 210 567 ...
BMJ

The impact of delays in computed tomography of the brain on the accuracy of diagnosis and subsequent management in patients with minor stroke

Correspondence to: Professor J Wardlaw, Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; jmw{at}skull.dcn.ed.ac.uk Objectives: To determine the ...
BMJ

The prevalence and causes of dementia in people under the age of 65 years

Objectives: To determine the prevalence of dementia in people under the age of 65 in a large catchment area, and use these figures to estimate the number of younger people affected by dementia in the ...
BMJ

Progression of cerebral white matter lesions in Alzheimer’s disease: a new window for therapy?

1 Alzheimer Centre and Department of Neurology, VU Medical Centre, Amsterdam, Netherlands 2 Department of Radiology VU Medical Centre 3 Department of Neurology, University Medical Centre St Radboud, ...
BMJ

High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology

Washington University School of Medicine, Department of Neurology, St Louis, Missouri, USA Dr A Pestronk, Washington University School of Medicine, Department of Neurology, Box 8111, 660 South Euclid ...
BMJ

LOPED study: looking for an early diagnosis in a late-onset Pompe disease high-risk population

20 Department of Neurosciences ‘Rita Levi Montalcini’, University of Turin, Turin, Italy Correspondence to Professor Antonio Toscano, Department of Neurosciences, University of Messina, Regional ...
BMJ

Paraneoplastic cochleovestibulopathy: clinical presentations, oncological and serological associations

Objective Cochleovestibulopathy is a distinguishable paraneoplastic phenotype. In this study, we evaluate clinical presentation, serological/cancer associations and outcomes of paraneoplastic ...
BMJ

Incidence and prediction of falls in Parkinson's disease: a prospective multidisciplinary study

2 Jubilee Day Hospital, North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear NE29 8NH, UK 3 North Tyneside General Hospital, Rake Lane, North Shields, Tyne and Wear, NE29 8NH, UK ...
BMJ

Detection of focal cerebral hemisphere lesions using the neurological examination

Objective: To determine the sensitivity and specificity of clinical tests for detecting focal lesions in a prospective blinded study. Methods: 46 patients with a focal cerebral hemisphere lesion ...
BMJ

Laughter, crying and sadness in ALS

Correspondence to Nimish J Thakore, Department of Neurology, Neuromuscular Center Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA; thakorn{at}ccf.org Background Pseudobulbar ...