Intraoperative dual-modality imaging can help the surgeon distinguish tumor from normal tissue. This technique may prove particularly valuable if small tumors need to be removed that are difficult to ...

Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer disease (AD) comes primarily from rodent models. However, unlike ...

Prostate-specific membrane antigen (PSMA) is a promising target in prostate cancer. Recently, we started the first-in-human treatment with an α-radionuclide–labeled PSMA ligand. Although the case ...

A semiquantitative scoring system was used to quantify the severity and frequency of hypoglycemic episodes under background antihypoglycemic therapy (somatostatin analogs, diazoxide, everolimus, or ...

It is now recognized that intratumoral heterogeneity is associated with more aggressive tumor phenotypes leading to poor patient outcomes ( [1] [1]). Medical imaging plays a central role in related ...

Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic, or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncologic applications.

See an invited perspective on this article on page 1412. Cancer-associated fibroblasts modulate the microenvironment of malignant tumors by secreting factors that regulate both malignant cells and ...

Journal of Nuclear Medicine September 2025, jnumed.125.270115; DOI: https://doi.org/10.2967/jnumed.125.270115 ...

Whole-body CD8+ T-cell PET imaging can detect spatial and temporal localization of CD8+ T cells. To obtain insight into early CD8+ T-cell response to immunotherapy in patients with melanoma, a highly ...

An essential prerequisite for a successful sentinel lymph node biopsy (SLNB) procedure is an accurate map of the pattern of lymphatic drainage from the primary tumor site in each patient. In melanoma ...

Journal of Nuclear Medicine September 2025, jnumed.125.270588; DOI: https://doi.org/10.2967/jnumed.125.270588 ...

The promise of prostate-specific membrane antigen (PSMA)–targeted radionuclide therapy is being demonstrated by a growing number of reports detailing institutional experience with various agents, and ...