Uncontrolled secretion of extracellular matrix (ECM) proteins such as collagen can lead to excessive scarring and fibrosis, and compromise tissue function. Researchers at the Center for Genomic ...

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

Cartilage injuries are a common clinical issue, often caused by trauma, severe infections, or degenerative joint diseases. The lack of direct blood supply to cartilage and limited access to nutrients ...

CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...