For Week 18 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 18 NFL schedule here. After analyzing every game in Week 18, the AI says the Rams (-7.5, 46.5), who have already clinched a postseason berth, cover comfortably against the Cardinals.

NFL Week 18 is here, so let's look at the odds and make some picks and predictions for the coming weekend as the playoffs near.

The Packers will go with third-string quarterback, Clayton Tune, and will likely spend most of this week prepping for the playoffs and a rematch with either the Bears or Eagles. The Packers are locked into the 7-seed. Don’t expect much scoring against a Minnesota defense that is playing great to finish the season.

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The Detroit Lions (8-8) visit the Chicago Bears (11-5) at Soldier Field in Chicago for a Week 18 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action. Here's everything you need to know before kickoff on Sunday, January 4, including live updated odds and injury report news.

NFL Week 18 picks, score predictions for every game this week, including Lions-Bears, Chargers-Broncos, Colts-Texans, Ravens-Steelers, Seahawks-49ers.

Cowboys (-3.5) at Giants: The Raiders understood the assignment in their Week 17 Tank Bowl loss against the Giants. This dumbass Giants team did not. The Giants are going to try to win this game too, but so will Dak Prescott, who has a chance to lead the NFL in passing yards.

Overall picks to win: 8-8 in Week 17 (173-82-1 for the season) Picks to win with 1-5 confidence: 4-7 (103-64-1) Picks to win with 6-10 confidence: 4-1 (70-18) Overall to cover the spread: 9-6-1 (130-117-9) Cover-the-spread picks with 1-5 confidence: 8-4-1 (107-93-8) Cover-the-spread picks with 6-10 confidence: 1-2 (23-23-1)

Florio’s pick: 49ers 27, Seahawks 24. Simms’s pick: Seahawks 28, 49ers 24. A meaningless game will have plenty of meaning, if Tampa wins on Saturday. Florio’s pick: Saints 23, Falcons 20. Simms’s pick: Falcons 24, Saints 17.

The Las Vegas Raiders are on the clock. Following the New York Giants' upset win over the Dallas Cowboys in Week 18, the Raiders officially secured the No. 1 overall pick in the 2026 NFL Draft. The Raiders were able to secure the No.