Ironically, the latest technique for producing transgenic cattle is based on a retroviral vector strategy reminiscent of that employed two decades ago to produce the first genetically engineered ...

Lentivirus and gamma retrovirus are two extremely popular retrovirus-based vectors currently being developed for novel gene and cell therapies. As of 2021, there were over three hundred products in ...

Previously it has been demonstrated that targeting of colorectal cancer cells can be effectively undertaken using the tumour-specific embryonic antigen (CEA) linked to CD. 25 The growth of tumours ...

The re-transcribed DNA is then integrated into the genome of the host cell (Figure 2). This process requires the absence of the nuclear membrane and thus is restricted to the M-phase of proliferating ...

Retroviruses are a sub-category of oncoviruses that include the lentiviruses. Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is ...

Viruses have been evolving for millions of years, improving their ability to transfer genetic material to the hosts they infect. When it comes to gene transfer, viruses are efficient and effective. So ...

Viral vectors are engineered viruses that are used to deliver genetic material into cells for various applications, such as gene therapy, vaccine development, and biotechnology research. These viruses ...

Gene therapy has been on a roller coaster in recent years. Experiments in adding genes directly to patients’ cells have shown promising signs, but the technical and clinical momentum has been drained ...

This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore tissues and organs damaged ...

Retroviruses are viruses that have evolved the ability to write their genetic code into a cell's own DNA. The most ancient known lineage of retroviruses, foamy viruses, emerged around 450 million ...

Phase I dose escalation study to assess tolerability and pharmacokinetics of recombinant human IL-18 (rhIL-18) administered as fourteen daily subcutaneous injections in patients with solid tumors No ...

Since the recombinant viral genomes are devoid of any viral genes (which are also not expressed by the infected target cell), the recombinant viral vectors can only infect a cell and are replication ...