How a retrovirus, like HIV, reproduces and assembles new viruses is different than previously thought, according to Penn State College of Medicine researchers. Understanding the steps a virus takes ...

A retrovirus is a virus that works by converting its own RNA into DNA once it is in a host cell. It then integrates this DNA into the DNA of the host cell, allowing the virus to replicate. Three ...

Integration of a cDNA copy of the viral RNA genome is essential to establish infection by retroviruses. This process (see, for example, ref. 10 for a review) is catalysed by the virus-encoded enzyme ...

Retroviruses are efficient vehicles for delivering transgenes in vivo. Their ability to integrate into the host genome, providing a permanent imprint of their genes in the host, is a key asset for ...

Robert Gifford does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond ...