G protein-coupled receptors (GPCRs) are found throughout the human body and are involved in many complex signaling pathways. Despite their importance in many biological processes, the central ...

Myeloid immune cells, such as dendritic cells (DCs) and macrophages are key sentinels of the immune system. They sense the presence of microbial species or altered self through pattern recognition ...

Congenital hyperinsulinism is a rare genetic disease characterized by overproduction of insulin. One class of potential treatments is insulin receptor antagonists like S961 and Ins-AC-S2, which ...

After earning notoriety as the first cellular receptor isolated and mammalian lectin identified, the Ashwell-Morell receptor's functions in our bodies eluded scientists for more than 30 years. In 2008 ...

Scientists are aiming to determine the composition and topology of physiological Ashwell-Morell receptor ligands. Their findings will help uncover the receptor's still-hidden secrets. After earning ...

To transmit excitatory signals, nerve cells mostly use glutamate as a neurotransmitter. To detect these transmitter signals, ...

The ability to grow stem cell-derived biological tissues, such as skin and other organs, in the laboratory holds promise for applications in areas including wound healing and transplants. However, ...

"To provide direct evidence for binding of the molecule at different pockets of the receptor, we have developed a new assay, which enables us to measure the binding specifically at the extracellular ...