After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta ...

Protein evolution is constrained by structure and function, creating patterns in residue conservation that are routinely exploited to predict structure and other features. Similar constraints should ...

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structures of protein kinase C beta ...

Isthmin-1 (ISM1) is a secreted protein initially identified in Xenopus embryos isthmus organizer 1. Despite broad tissue expression in mammals 2, the precise functions of ISM1 remain to be fully ...

Enzymes are regarded as the key to sustainable chemistry. Despite major advances in protein design, creating artificial enzymes from scratch has so far remained a grand challenge. A research team at ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

Low-complexity domains in proteins are composed of a small subset of the full complement of amino acids, and in these domains, the amino acid sequences are often repetitive. Their relevance to health ...

Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

Scientists at UT Southwestern Medical Center, working with other U.S. researchers, have uncovered the structure of a key cell membrane protein in a bacterial model for Chlamydia trachomatis, the cause ...

Researchers from the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, together with collaborators from ETH Zürich, the Malopolska Center of Biotechnology and the ...