The researchers discovered that the lipid phosphatidylinositol-4-phosphate (PI4P)—usually scarce in the ER—acts as a ...

Just like in yeast and animal cells, vacuoles in plants are responsible for breaking down unwanted cellular components. At ...

Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate conformation. Much of this processing occurs in the endoplasmic reticulum ...

How does skin hold you in? How do heart cells beat together? Researchers at the University of California, Davis, Department ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

Thousands of previously undescribed protein–metabolite interactions have been mapped by analysing outbred mice.

Activating lysosome biogenesis helps alleviate cellular senescence in progeria. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition that causes rapid aging and a range of visible ...

The discovery positions IGF2BP3 as a "master switch" in leukaemia, linking metabolism and RNA regulation, processes long ...

Scientists have developed compounds that selectively block a crucial interaction between RAS and the enzyme PI3K, a driver of tumor growth. Scientists from the Francis Crick Institute and Vividion The ...