The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it ...

When scientists first came across p53 in 1979, it was an intriguing but not Earth-shattering discovery. Six groups independently discovered a cellular protein with a molecular weight of roughly 53 ...

Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Mutations in tumor suppressor genes can allow tumors to ...

The p53 protein, is a tumor suppressor often inactivated in cancers by gene mutations or the inhibition by overexpressed MDM2 and MDM4 (X). Pharmacological reactivation of wild-type p53 protein, or ...

Researchers have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the ...

India, May 28 -- AI-Designed p53 Proteins may help improve future cancer treatment, but the research is still at an early and ...

A new study revealed how defects in the final stage of cell division disrupt brain development and may contribute to cancer.