Here is the full Major League Baseball schedule for Sept. 16 and how to watch all the games. Or see our sortable MLB schedule to filter by team or division. All times Eastern and accurate as of Tuesday, Sept. 16, 2025, at 4:41 a.m. From NFL plays to college sports scores, all the top sports news you need to know every day.

This article was originally published on www.si.com/mlb/cubs as Chicago Cubs Game Today (9/16/25): Start Time, Pitchers, How to Watch & Live Stream. The Chicago Cubs will be looking to win their series with the Pittsburgh Pirates when they face each other on Tuesday night at PNC Park.

The New York Yankees take aim at a much-needed road sweep of the Boston Red Sox as they get set for a Sunday night finale at Fenway Park.

The St. Louis Cardinals face the Milwaukee Brewers on Saturday, Sept. 13, 2025 (9/13/25) in a regular season MLB game at American Family Field in Milwaukee, Wisc.

Even with Monday’s win, the Astros stand 1/2 game back of the Mariners. As a result, the Mariners would play host to a scuffling club that saw Yordan Alvarez suffer a left ankle sprain . The Yankees similarly would play host to their long-time rival Red Sox in the AL’s other best-of-three series.

Things are getting serious in this baseball season. With three weeks left in the season and division races and wild-card

Pregame analysis and predictions of the Texas Rangers vs. Houston Astros MLB game to be played on September 15, 2025 on ESPN.

Whether your favorite team is a postseason lock or lacks October intrigue, there’s always something worth watching in the final few weeks.