Professor Xiaokong Liu's team at Jilin University proposed an "activation-quenching" strategy for dynamic covalent chemistry, ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

BUFFALO, N.Y. — One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent ...

Covalent chemical probes – chemical probes that form a covalent bond with their target biomacromolecule(s) represent powerful tools that can be used for biology discovery, target validation (or ...

Avalon BioVentures managing partners Sergio Duron and Sandy Madigan hadn’t even left their previous start-up when they hatched the idea for Enlaza Therapeutics. While they were both still at Nerio ...