Alternative splicing (AS) is a major contributor to transcriptome and proteome diversity. Evolutionary studies help to address questions that are fundamental to understanding this important process.

All recent studies have concluded that large-scale mutation screenings of HCM patients, where eight or nine sarcomeric genes are screened, identify mutations in 35–60% of diagnosed patients. 2 One ...

Over two decades after the first human genome was sequenced, a team of researchers has discovered ~1 million new exons in the human genome. The research group, from the University of Toronto’s (U of T ...