In patients with heart failure with reduced ejection fraction (HFrEF) who have an implantable cardioverter-defibrillator (ICD), the use of digoxin may increase the risk of ventricular tachyarrhythmia ...

Digoxin, originally derived from the foxglove flower, blocks the sodium/potassium ATPase pump. The mechanism by which this decreases atrioventricular (AV) conduction is not clear, butperhaps it is due ...

Explaination: As previously stated, digoxin toxicity itself results in hyperkalemia, however hypokalemia significantly increases the risk for serious arrhythmias in the digoxin toxic patient. Digoxin ...

Andrew McLachlan is the Program Director for the NHMRC Centre for Resarch Excellence in Medicines and Ageing. He was an investigator on the PACE trial (ACTRN 12609000966291) which was an ...