Organ-on-a-chip platforms have revolutionized the modelling of cardiovascular pathophysiology, enabling researchers to elucidate underlying mechanisms and drug responses for a variety of inherited and ...

Chronic heart failure (CHF) is a terminal condition resulting from various heart diseases, including cardiac structural abnormalities or insufficient myocardial function, which eventually lead to ...

Researchers from the Centenary Institute and the University of Technology Sydney (UTS) have developed a human heart cell model demonstrating that the virus that causes COVID-19 (SARS-CoV-2) can ...

While current clinical trials for cardiac regeneration using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) employ immunosuppressive regimens used in heart transplants, the precise ...

The adult mammalian heart bears limited regenerative capacity, resulting in the irreversible loss of cardiomyocytes post-cardiac injury, and often culminating in end-stage heart failure. Cardiomyocyte ...

In developing hearts, cells shuffle around, bumping into each other to find their place, and the stakes are high: pairing with the wrong cell could mean the difference between a beating heart and one ...

Heart disease is the top cause of death in the United States, resulting in one in three deaths in 2023. In addition to being such a vital organ, the adult heart, unlike other parts of the body, cannot ...

In developing hearts, cells shuffle around, bumping into each other to find their place, and the stakes are high: pairing with the wrong cell could mean the difference between a beating heart and one ...

The heart's constant beating may actively suppress tumor growth in cardiac tissues, a new study reports. This is because cellular pathways in these tissues alter gene regulation in cancer cells to ...

The heart (cyan) forms from two distant regions of the embryo (far left). These regions migrate to the embryo midline, where they fuse into a tube to make the first heart structure (far right).