The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

San Francisco 49ers wide receiver Ricky Pearsall has missed the team's first practice of the week due to knee and ankle injuries.

The other result matters now that the sixth seed has won. Chicago finishes as the No. 2 seed and hosts the Packers. This simulation has Green Bay winning comfortably, which means San Francisco travels to Tampa Bay, and the Packers face the Rams.

Brock Purdy opens up about his game-day philosophy as San Francisco surges toward the playoffs after a big win over the Titans.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

SANTA CLARA – Here is how the 49ers (10-4) graded in Sunday’s 37-24 home win over the Tennessee Titans (2-11):

By far, the worst unit on the San Francisco 49ers is their pass rushers. Injuries have decimated this area. They don’t have Nick Bosa and rookie Mykel Williams

The Indianapolis Colts get a crucial update on the status of former first-round pick quarterback Anthony Richardson.

See the Titans vs 49ers game stats from the 37-24 loss on Dec. 14, 2025, including match player stats and team stats.

While the San Francisco 49ers have won their last four games, a few of their players have dropped in the newest fan voting update for the Pro Bowl.

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in the throes of tense, tight division races where one more loss could eliminate them. Both are also trying to lock up playoff spots. And both face a daunting final three games against three potential playoff teams.