No position affects NFL odds quite like who is under center, so having the proper NFL betting advice would set you up for a profitable week.

The Minnesota Vikings will play the Los Angeles Chargers during Week 8 of the 2025 NFL season.

The Minnesota Vikings and Los Angeles Chargers will air on Prime at 8:15 p.m. Thursday, Oct. 23, 2025: The Minnesota Vikings and Los Angeles Chargers will stream on Prime and NFL+ at 8:15 p.m. Thursda...

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Los Angeles dominated Minnesota, 37-10.

The Chargers have now lost three of their last four since starting the season 3-0, and they're still dealing with a rash of injuries as they look to keep pace in the AFC West.

It's the Mac Jones show for the 49ers for at least one more week as Brock Purdy is out with a toe injury that's caused him to miss all but two contests this season. Jones is 4-1 as a starter in Purdy's absence. The 49ers will also be without receiver Ricky Pearsall once again as he battles a knee injury.

"He is close," NFL Network's Ian Rapoport reported Thursday.

With Brown out of the lineup, the Eagles will heavily rely on DeVonta Smith in the passing game.

The outings include the San Francisco 49ers squaring off against the Houston Texans at NRG Stadium.

Tonight the Los Angeles Chargers host the Minnesota Vikings.